用于重组蛋白递送和免疫系统治疗调节的封装细胞植入物。
Encapsulated cellular implants for recombinant protein delivery and therapeutic modulation of the immune system.
作者信息
Lathuilière Aurélien, Mach Nicolas, Schneider Bernard L
机构信息
Division of Neurology, Department of clinical Neuroscience, Geneva University Hospitals, 1205 Geneva, Switzerland.
Neurodegenerative Studies Laboratory, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
出版信息
Int J Mol Sci. 2015 May 8;16(5):10578-600. doi: 10.3390/ijms160510578.
Ex vivo gene therapy using retrievable encapsulated cellular implants is an effective strategy for the local and/or chronic delivery of therapeutic proteins. In particular, it is considered an innovative approach to modulate the activity of the immune system. Two recently proposed therapeutic schemes using genetically engineered encapsulated cells are discussed here: the chronic administration of monoclonal antibodies for passive immunization against neurodegenerative diseases and the local delivery of a cytokine as an adjuvant for anti-cancer vaccines.
使用可回收封装细胞植入物的离体基因治疗是局部和/或长期递送治疗性蛋白质的有效策略。特别是，它被认为是一种调节免疫系统活性的创新方法。本文讨论了最近提出的两种使用基因工程封装细胞的治疗方案：长期施用单克隆抗体以被动免疫预防神经退行性疾病，以及局部递送细胞因子作为抗癌疫苗的佐剂。
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