人乳头瘤病毒相关头颈癌的疫苗策略
Vaccine Strategies for Human Papillomavirus-Associated Head and Neck Cancers.
作者信息
Zhou Jade Z, Jou Jessica, Cohen Ezra
机构信息
Division of Hematology and Oncology, School of Medicine, University of California, San Diego, CA 92037, USA.
Division of Gynecologic Oncology, Moores Cancer Center, University of California, San Diego, CA 92037, USA.
出版信息
Cancers (Basel). 2021 Dec 22;14(1):33. doi: 10.3390/cancers14010033.
Abstract
The rising incidence of oropharyngeal squamous cell cancers (OPSCC) in the United States is largely attributed to HPV. Prophylactic HPV vaccines have demonstrated effectiveness against oral infection of HPV 16 and HPV 18. We review the global epidemiology and biology of HPV-related cancers as well as the development of HPV vaccines and their use worldwide. We also review the various strategies and challenges in development of therapeutic HPV vaccines.
摘要
美国口咽鳞状细胞癌（OPSCC）发病率的上升在很大程度上归因于人乳头瘤病毒（HPV）。预防性HPV疫苗已证明对HPV 16和HPV 18的口腔感染有效。我们综述了HPV相关癌症的全球流行病学和生物学，以及HPV疫苗的研发及其在全球的应用。我们还综述了治疗性HPV疫苗研发中的各种策略和挑战。
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