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Lysosomes to combat Parkinson's disease.

作者信息

Isacson Ole

机构信息

Neuroregeneration Research Institute, Harvard Medical School, Harvard Stem Cell Institute and McLean Hospital, Belmont, Massachusetts, USA.

出版信息

Nat Neurosci. 2015 Jun;18(6):792-3. doi: 10.1038/nn.4027.

DOI:10.1038/nn.4027

PMID:26007211

Abstract

摘要

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Lmx1b can promote the differentiation of embryonic stem cells to dopaminergic neurons associated with Parkinson's disease.

Biotechnol Lett. 2012 Jul;34(7):1167-74. doi: 10.1007/s10529-012-0888-5. Epub 2012 Mar 17.

Drosophila eye developmental defect caused by elevation of the activity of the LIM-homeodomain protein, Lmx1a, requires its association with the Co-activator Chip.

Biochem Biophys Res Commun. 2016 Jan 29;470(1):29-34. doi: 10.1016/j.bbrc.2015.12.089. Epub 2015 Dec 21.

Lmx1a enhances the effect of iNSCs in a PD model.

Stem Cell Res. 2015 Jan;14(1):1-9. doi: 10.1016/j.scr.2014.10.004. Epub 2014 Oct 18.

引用本文的文献

BMP4, SGSH, and SLC11A2 are Predicted to Be Biomarkers of Aging Associated with Programmed Cell Death.

J Mol Neurosci. 2023 Oct;73(9-10):713-723. doi: 10.1007/s12031-023-02148-5. Epub 2023 Aug 26.

Integrated molecular landscape of Parkinson's disease.

NPJ Parkinsons Dis. 2017 Apr 10;3:14. doi: 10.1038/s41531-017-0015-3. eCollection 2017.

本文引用的文献

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.

Nat Neurosci. 2015 Jun;18(6):826-35. doi: 10.1038/nn.4004. Epub 2015 Apr 27.

Progressive decline of glucocerebrosidase in aging and Parkinson's disease.

Ann Clin Transl Neurol. 2015 Apr;2(4):433-8. doi: 10.1002/acn3.177. Epub 2015 Feb 6.

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease.

Neurobiol Dis. 2014 Apr;64(100):79-87. doi: 10.1016/j.nbd.2013.12.011. Epub 2013 Dec 31.

The role of autophagy in neurodegenerative disease.

Nat Med. 2013 Aug;19(8):983-97. doi: 10.1038/nm.3232. Epub 2013 Aug 6.

Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages.

J Neurosci. 2013 May 1;33(18):8022-34. doi: 10.1523/JNEUROSCI.4774-12.2013.

TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1817-26. doi: 10.1073/pnas.1305623110. Epub 2013 Apr 22.

Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains.

Ann Neurol. 2012 Sep;72(3):455-63. doi: 10.1002/ana.23614.

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies.

Cell. 2011 Jul 8;146(1):37-52. doi: 10.1016/j.cell.2011.06.001. Epub 2011 Jun 23.

TFEB links autophagy to lysosomal biogenesis.

Science. 2011 Jun 17;332(6036):1429-33. doi: 10.1126/science.1204592. Epub 2011 May 26.

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1.

Nature. 2010 Dec 2;468(7324):696-700. doi: 10.1038/nature09536. Epub 2010 Nov 10.

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相似文献

Lysosomes to combat Parkinson's disease.

Nat Neurosci. 2015 Jun;18(6):792-3. doi: 10.1038/nn.4027.

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.

Nat Neurosci. 2015 Jun;18(6):826-35. doi: 10.1038/nn.4004. Epub 2015 Apr 27.

Autophagy impairment in Parkinson's disease.

Essays Biochem. 2017 Dec 12;61(6):711-720. doi: 10.1042/EBC20170023.

[Autophagy-lysosome pathway and Parkinson's disease].

Sheng Li Ke Xue Jin Zhan. 2010 Aug;41(4):272-4.

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy.

J Clin Invest. 2008 Feb;118(2):777-88. doi: 10.1172/JCI32806.

Autophagy: Surviving stress in pancreatic cancer.

Nat Rev Cancer. 2015 Sep;15(9):513. doi: 10.1038/nrc4005.

Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies.

Mov Disord. 2016 Feb;31(2):178-92. doi: 10.1002/mds.26477. Epub 2016 Jan 27.

Lmx1b can promote the differentiation of embryonic stem cells to dopaminergic neurons associated with Parkinson's disease.

Biotechnol Lett. 2012 Jul;34(7):1167-74. doi: 10.1007/s10529-012-0888-5. Epub 2012 Mar 17.

Drosophila eye developmental defect caused by elevation of the activity of the LIM-homeodomain protein, Lmx1a, requires its association with the Co-activator Chip.

Biochem Biophys Res Commun. 2016 Jan 29;470(1):29-34. doi: 10.1016/j.bbrc.2015.12.089. Epub 2015 Dec 21.

Lmx1a enhances the effect of iNSCs in a PD model.

Stem Cell Res. 2015 Jan;14(1):1-9. doi: 10.1016/j.scr.2014.10.004. Epub 2014 Oct 18.

引用本文的文献

BMP4, SGSH, and SLC11A2 are Predicted to Be Biomarkers of Aging Associated with Programmed Cell Death.

J Mol Neurosci. 2023 Oct;73(9-10):713-723. doi: 10.1007/s12031-023-02148-5. Epub 2023 Aug 26.

Integrated molecular landscape of Parkinson's disease.

NPJ Parkinsons Dis. 2017 Apr 10;3:14. doi: 10.1038/s41531-017-0015-3. eCollection 2017.

本文引用的文献

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.

Nat Neurosci. 2015 Jun;18(6):826-35. doi: 10.1038/nn.4004. Epub 2015 Apr 27.

Progressive decline of glucocerebrosidase in aging and Parkinson's disease.

Ann Clin Transl Neurol. 2015 Apr;2(4):433-8. doi: 10.1002/acn3.177. Epub 2015 Feb 6.

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease.

Neurobiol Dis. 2014 Apr;64(100):79-87. doi: 10.1016/j.nbd.2013.12.011. Epub 2013 Dec 31.

The role of autophagy in neurodegenerative disease.

Nat Med. 2013 Aug;19(8):983-97. doi: 10.1038/nm.3232. Epub 2013 Aug 6.

Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages.

J Neurosci. 2013 May 1;33(18):8022-34. doi: 10.1523/JNEUROSCI.4774-12.2013.

TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1817-26. doi: 10.1073/pnas.1305623110. Epub 2013 Apr 22.

Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains.

Ann Neurol. 2012 Sep;72(3):455-63. doi: 10.1002/ana.23614.

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies.

Cell. 2011 Jul 8;146(1):37-52. doi: 10.1016/j.cell.2011.06.001. Epub 2011 Jun 23.

TFEB links autophagy to lysosomal biogenesis.

Science. 2011 Jun 17;332(6036):1429-33. doi: 10.1126/science.1204592. Epub 2011 May 26.

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1.

Nature. 2010 Dec 2;468(7324):696-700. doi: 10.1038/nature09536. Epub 2010 Nov 10.

Lysosomes to combat Parkinson's disease.

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