钯催化异丁腈插入反应化学选择性合成茚满-1,3-二酮衍生物

Palladium-catalyzed chemoselective synthesis of indane-1,3-dione derivatives via tert-butyl isocyanide insertion.

作者信息

Duan Huaqing, Chen Zhong, Han Li, Feng Yulin, Zhu Yongming, Yang Shilin

机构信息

College of Pharmaceutical Science, Soochow University, 199 Ren-ai Road, Suzhou 215123, China.

出版信息

Org Biomol Chem. 2015 Jun 28;13(24):6782-8. doi: 10.1039/c5ob00472a.

DOI:10.1039/c5ob00472a

PMID:26007325

Abstract

A simple and efficient strategy for the synthesis of indane-1,3-dione derivatives through a palladium(0)-catalyzed reaction incorporating tert-butyl isocyanide has been developed. In addition, by applying this protocol as the key step, indenopyrazole derivatives can be easily synthesized in high yields in a one-pot procedure. This methodology is tolerant of a wide range of substrates and applicable to library synthesis.

摘要

已开发出一种简单高效的策略，通过钯（0）催化的、结合叔丁基异腈的反应来合成茚满-1,3-二酮衍生物。此外，通过将该方案作为关键步骤，茚并吡唑衍生物可以在一锅法中以高产率轻松合成。该方法对多种底物具有耐受性，适用于文库合成。