钯催化异氰化物插入反应的最新进展。

Department of Chemistry and Pharmaceutical Sciences and Amsterdam Institute for Molecules, Medicines & Systems (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.

Organic Synthesis, Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium.

Molecules. 2020 Oct 23;25(21):4906. doi: 10.3390/molecules25214906.

Isocyanides have long been known as versatile chemical reagents in organic synthesis. Their ambivalent nature also allows them to function as a CO-substitute in palladium-catalyzed cross couplings. Over the past decades, isocyanides have emerged as practical and versatile C building blocks, whose inherent -substitution allows for the rapid incorporation of nitrogeneous fragments in a wide variety of products. Recent developments in palladium catalyzed isocyanide insertion reactions have significantly expanded the scope and applicability of these imidoylative cross-couplings. This review highlights the advances made in this field over the past eight years.

异氰化物在有机合成中一直是一种用途广泛的化学试剂。它们的两亲性也使它们能够在钯催化的交叉偶联反应中替代 CO。在过去的几十年中，异氰化物已经成为实用且多功能的 C 构建块，其固有取代基允许在各种产品中快速引入含氮片段。近年来，钯催化的异氰化物插入反应的发展显著扩展了这些酰亚胺交叉偶联的范围和适用性。本综述重点介绍了过去八年中该领域的进展。