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多倍体不断扩大的影响。

The expanding implications of polyploidy.

作者信息

Schoenfelder Kevin P, Fox Donald T

机构信息

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710

出版信息

J Cell Biol. 2015 May 25;209(4):485-91. doi: 10.1083/jcb.201502016.

DOI:10.1083/jcb.201502016
PMID:26008741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4442802/
Abstract

Polyploid cells, which contain more than two genome copies, occur throughout nature. Beyond well-established roles in increasing cell size/metabolic output, polyploidy can also promote nonuniform genome, transcriptome, and metabolome alterations. Polyploidy also frequently confers resistance to environmental stresses not tolerated by diploid cells. Recent progress has begun to unravel how this fascinating phenomenon contributes to normal physiology and disease.

摘要

多倍体细胞含有两个以上的基因组拷贝，在自然界中广泛存在。除了在增加细胞大小/代谢产出方面已明确的作用外，多倍体还可促进基因组、转录组和代谢组的非均匀改变。多倍体还常常赋予细胞对二倍体细胞无法耐受的环境压力的抗性。最近的研究进展已开始揭示这一迷人现象如何影响正常生理和疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a4d/4442802/2822f2932aee/JCB_201502016_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a4d/4442802/503d4d7fc9e0/JCB_201502016_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a4d/4442802/2822f2932aee/JCB_201502016_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a4d/4442802/503d4d7fc9e0/JCB_201502016_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a4d/4442802/2822f2932aee/JCB_201502016_Fig2.jpg

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