Alstrom Jette Skov, Stroemlund Line Waring, Nielsen Morten Schak, MacAulay Nanna
*Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
†Danish National Research Foundation Centre for Cardiac Arrhythmia and Department of Biomedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Biochem Soc Trans. 2015 Jun;43(3):519-23. doi: 10.1042/BST20150040.
Connexin43 (Cx43) generates intercellular gap junction channels involved in, among others, cardiac and brain function. Gap junctions are formed by the docking of two hemichannels from neighbouring cells. Undocked Cx43 hemichannels can upon different stimuli open towards the extracellular matrix and allow transport of molecules such as fluorescent dyes and ATP. A range of phosphorylated amino acids have been detected in the C-terminus of Cx43 and their physiological role has been intensively studied both in the gap junctional form of Cx43 and in its hemichannel configuration. We present the current knowledge of protein kinase C (PKC)-dependent regulation of Cx43 and discuss the divergent results.
连接蛋白43（Cx43）形成细胞间缝隙连接通道，参与心脏和大脑功能等多种生理过程。缝隙连接由相邻细胞的两个半通道对接形成。未对接的Cx43半通道在不同刺激下可向细胞外基质开放，允许荧光染料和ATP等分子运输。在Cx43的C末端已检测到一系列磷酸化氨基酸，并且对它们在Cx43缝隙连接形式及其半通道构型中的生理作用进行了深入研究。我们介绍了目前关于蛋白激酶C（PKC）依赖性调节Cx43的知识，并讨论了不同的研究结果。
