Iwegbue Chukwujindu M A
Department of Chemistry, Delta State University, P.M.B. 1, Abraka, Nigeria.
Regul Toxicol Pharmacol. 2015 Aug;72(3):630-8. doi: 10.1016/j.yrtph.2015.05.020. Epub 2015 May 23.
The concentrations of metals (Cd, Pb, Ni, Cr, Cu, Co, Fe, Mn, Zn and Al) were determined in thirty brands of popular of underarm cosmetics in Nigeria with a view to providing information on the levels of metals and the risk of exposure to metals by humans through long time usage of these products. The concentrations of metals in these samples of underarm cosmetics were measured by using atomic absorption spectrometry after acid digestion. The concentrations of metals in these types of underarm cosmetics studied ranged from <0.15 to 1.2 μg g(-1)Cd, <0.02 to 11.2 μg g(-1)Pb, <0.03 to 4.9 μg g(-1)Ni, <0.1 to 25.0 μg g(-1), <0.02 to 2.8 μg g(-1)Co, 2.0 to 6.4 μg g(-1)Cu, 4.7 to 91.2 μg g(-1)Fe, <0.05 to 14.1 μg g(-1)Mn, 77.9 to 132 μg g(-1) and 69.2 to 83,500 μg g(-1)Al. The results of this study indicate that Cd, Pb, Ni, Cr and Co were presents in these types of underarm cosmetics at concentrations below the regulatory control limits for metal impurities in color additives for cosmetics and suggested limits following good manufacturing practice. The estimated margin of safety (MoS) indicated that the concentrations of the examined metals in these underarm cosmetic products present no potential risk to the users. The continuous use of these brands of underarm cosmetics represents a potential source of human exposure to metals such as aluminum in the local area of the breast, particularly to the upper outer quadrant.
测定了尼日利亚30个品牌流行的腋下化妆品中的金属(镉、铅、镍、铬、铜、钴、铁、锰、锌和铝)浓度,旨在提供有关金属含量以及人类长期使用这些产品接触金属的风险的信息。这些腋下化妆品样品中的金属浓度在酸消解后采用原子吸收光谱法进行测量。所研究的这类腋下化妆品中的金属浓度范围为:镉<0.15至1.2μg g⁻¹,铅<0.02至11.2μg g⁻¹,镍<0.03至4.9μg g⁻¹,铬<0.1至25.0μg g⁻¹,钴<0.02至2.8μg g⁻¹,铜2.0至6.4μg g⁻¹,铁4.7至91.2μg g⁻¹,锰<0.05至14.1μg g⁻¹,锌77.9至132μg g⁻¹,铝69.2至83500μg g⁻¹。本研究结果表明,这些类型的腋下化妆品中镉、铅、镍、铬和钴的含量低于化妆品色素添加剂中金属杂质的监管控制限值以及良好生产规范建议的限值。估计的安全边际表明,这些腋下化妆品中所检测金属的浓度对使用者不存在潜在风险。持续使用这些品牌的腋下化妆品是人类在乳房局部区域,特别是上外象限接触铝等金属的潜在来源。