Ichimaru M, Tsukazaki K, Ikeda S
Rinsho Ketsueki. 1989 Aug;30(8):1208-11.
128 cases of ATL (adult T-cell leukemia/lymphoma) were divided into 3 subgroups, 70 cases of acute type, 19 cases of chronic type and 39 cases of lymphoma type, and their prognosis were evaluated. Median survival time from the onset of acute type using Kaplan-Meier method was 8 months, that of lymphoma type was 14 months and that of chronic type was 50 months. Median survival time from the start of treatment of acute type was 5 months, that of lymphoma type was 11 months and that of chronic type was 22 months. Relatively short median survival time of chronic type may be due to they had some duration with observation only at first. No significant elongation of survival time could be obtained when acute type was divided into 2 stages, before and after 1982. Twelve patients with non-Hodgkins' lymphoma unresponsive to the first line combination chemotherapy were treated with combination therapy with cis-dichlorodiammineplatinum (CDDP). Ten patients were evaluable for response (4 cases of CR, 6 cases of PR). To stop the HTLV-1 carrier mothers milk for giving their children seems to be effective method to decrease the occurrence of ATL in future.
128例成人T细胞白血病/淋巴瘤（ATL）患者被分为3个亚组，急性型70例、慢性型19例、淋巴瘤型39例，并对其预后进行评估。采用Kaplan-Meier法计算，急性型从发病开始的中位生存时间为8个月，淋巴瘤型为14个月，慢性型为50个月。急性型从开始治疗起的中位生存时间为5个月，淋巴瘤型为11个月，慢性型为22个月。慢性型中位生存时间相对较短可能是因为最初有一段时间仅进行观察。将急性型按1982年前后分为两个阶段时，生存时间无显著延长。12例对一线联合化疗无反应的非霍奇金淋巴瘤患者接受了顺二氯二氨铂（CDDP）联合治疗。10例患者可评估疗效（4例完全缓解，6例部分缓解）。停止HTLV-1携带母亲对孩子进行母乳喂养似乎是未来降低ATL发生率的有效方法。
