Kawabe T, Kaneoka A, Koichi K, Murakami N, Kuroki T, Kinugasa M, Miyake S, Takasu K
Rinsho Byori. 1989 Oct;37(10):1167-72.
Study on detection of malignant cells in urinary sediments using supravital staining was described. We examined 96,554 specimens of urinary sediments for 2 years from January 1985 to December 1986. The results of microscopic urinalysis were compared with the cytological and histological diagnoses. Atypical cells were found in 138 patients, and 47 (34.1%) cancers were diagnosed histologically among them. These included 33 bladder cancer, 1 ureter cancer, 1 renal pelvic cancer, 2 prostate cancers, 1 rectal cancer, and 9 uterine cancers. Seven patients of them had not been under suspicion of malignancy yet before atypical cells were detected. Therefore microscopic urinalysis caused the triggers of cancer diagnoses. For bladder cancers, the positive rates in microscopic urinalysis were 43.4%, and those in urinary cytology were 52.4%. The positivity revealed higher in high-grade cancers than in low-grade. As compared with the results between microscopic urinalysis and urinary cytology in identical patients, the rate of correspondence between them was 89.5%. In 61.2% of positive and suspicious urinary cytology, atypical cells were not found. Atypical cells were seen in negative urinary cytology of 26 cases, and 5 cases of cancers were diagnosed histologically. These suggested that microscopic urinalysis as a screening for malignant cells was useful to detect urinary tract malignancy combining with urinary cytology.
描述了一项关于使用活染法检测尿沉渣中恶性细胞的研究。1985年1月至1986年12月的两年间，我们检查了96554份尿沉渣标本。将显微镜下尿液分析结果与细胞学和组织学诊断结果进行了比较。在138例患者中发现了非典型细胞，其中47例（34.1%）经组织学诊断为癌症。这些包括33例膀胱癌、1例输尿管癌、1例肾盂癌、2例前列腺癌、1例直肠癌和9例子宫癌。其中7例在检测到非典型细胞之前尚未被怀疑患有恶性肿瘤。因此，显微镜下尿液分析引发了癌症诊断。对于膀胱癌，显微镜下尿液分析的阳性率为43.4%，尿液细胞学的阳性率为52.4%。高级别癌症的阳性率高于低级别癌症。与同一患者的显微镜下尿液分析和尿液细胞学结果相比，两者之间的符合率为89.5%。在61.2%的阳性和可疑尿液细胞学检查中，未发现非典型细胞。在26例尿液细胞学阴性的病例中发现了非典型细胞，其中5例经组织学诊断为癌症。这些表明，显微镜下尿液分析作为恶性细胞的筛查方法，结合尿液细胞学检查，对检测尿路恶性肿瘤是有用的。
