Matsuda H
Rinsho Hoshasen. 1989 Oct;34(11):1327-35.
Brain perfusion SPECT imaging has been applied to patients with dementia using 123I-IMP and 99mTc-HM-PAO. Brain blood flow closely parallels regional brain metabolism or brain function with normal cerebrovascular function. Therefore neuronal activity can be indirectly evaluated by in vivo brain perfusion imaging in dementia. This nuclear medicine technique is quite useful for the differential diagnosis, assessment of the degree and localization of the affected area, disease course, and therapeutic effect. IMP seems to be superior to HM-PAO in detecting focal decreased perfusion and quantitative analysis. Hereafter the brain perfusion SPECT study will be more widespread. Neuroreceptor imaging is highly expected as the next step of a brain SPECT study.
脑灌注单光子发射计算机断层显像（SPECT）已使用123I-异丁基安非他明（IMP）和99m锝-六甲基丙烯胺肟（HM-PAO）应用于痴呆患者。在正常脑血管功能状态下，脑血流量与局部脑代谢或脑功能密切平行。因此，在痴呆症中可通过活体脑灌注成像间接评估神经元活动。这种核医学技术对于鉴别诊断、评估病变区域的程度和定位、病程及治疗效果非常有用。在检测局部灌注减少和定量分析方面，IMP似乎优于HM-PAO。此后，脑灌注SPECT研究将会更加广泛。作为脑SPECT研究的下一步，神经受体成像备受期待。
