水合氯醛的预处理位置偏爱疗法可阻断吗啡的奖赏效应。
Pre-conditioned place preference treatment of chloral hydrate interrupts the rewarding effect of morphine.
作者信息
Sun YongMei, Zong Wei, Zhou MuRu, Ma YuanYe, Wang JianHong
机构信息
Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China; Department of Molecular and Cellular Neurobiology, Center for Neurogenomics & Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, Netherlands.
Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China.
出版信息
Pharmacol Biochem Behav. 2015 Aug;135:60-3. doi: 10.1016/j.pbb.2015.05.010. Epub 2015 May 23.
The medical use of morphine as a pain killer is hindered by its side effects including dependence and further addiction. As the prototypical μ receptor agonist, morphine's rewarding effect can be measured by conditioned place preference (CPP) paradigms in animals. Chloral hydrate is a clinical sedative. Using a morphine CPP paradigm that mainly contains somatosensory cues, we found that pre-CPP treatment in rats using chloral hydrate for 6 consecutive days could disrupt the establishment of CPP in a U shape. Chloral hydrate had no effect on the body weight of rats. Our results indicate that prior treatment with chloral hydrate can interrupt the rewarding effect of morphine.
吗啡作为止痛剂的医学应用因其副作用（包括依赖性和进一步成瘾）而受到阻碍。作为典型的μ受体激动剂，吗啡的奖赏效应可以通过动物的条件性位置偏爱（CPP）范式来衡量。水合氯醛是一种临床镇静剂。使用主要包含体感线索的吗啡CPP范式，我们发现，在大鼠中，于CPP建立前连续6天使用水合氯醛进行预处理，会呈U形干扰CPP的建立。水合氯醛对大鼠体重没有影响。我们的结果表明，用水合氯醛进行预处理可以中断吗啡的奖赏效应。
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