Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics & Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, The Netherlands.
CNS Neurosci Ther. 2018 May;24(5):420-428. doi: 10.1111/cns.12799. Epub 2018 Jan 9.
The heterogeneous insular cortex plays an interoceptive role in drug addiction by signaling the availability of drugs of abuse. Here, we tested whether the caudal part of the multisensory posterior insula (PI) stores somatosensory-associated rewarding memories. Using Sprague Dawley rats as subjects, we first established a morphine-induced conditioned place preference (CPP) paradigm, mainly based on somatic cues. Secondly, an electrolytic lesion of the caudal portion of the PI was carried out before and after the establishment of CPP, respectively. Our data demonstrated that the caudal PI lesions disrupted the maintenance, but not the acquisition of morphine-induced CPP. Lesion or subtle disruption of the PI had no major impact on locomotor activity. These findings indicate that the caudal portion of the PI might be involved in either the storage or the retrieval of morphine CPP memory.
异质岛叶皮层通过信号传递滥用药物的可用性在药物成瘾中发挥着内脏感觉作用。在这里，我们测试了多感觉后岛叶（PI）的尾部是否储存与躯体感觉相关的奖赏记忆。使用 Sprague Dawley 大鼠作为研究对象，我们首先建立了基于躯体线索的吗啡诱导条件性位置偏爱（CPP）范式。其次，分别在 CPP 建立前后对 PI 的尾部进行电解损伤。我们的数据表明，PI 的尾部损伤破坏了吗啡诱导 CPP 的维持，但不影响其获得。PI 的损伤或细微破坏对运动活动没有重大影响。这些发现表明，PI 的尾部可能参与吗啡 CPP 记忆的存储或检索。
