Matata Sébastien Ngilima, Nkidiaka Emmanuel Dimbu, Aloni Michel Ntetani
Division of Hemato-oncology and Nephrology, Department of Pediatrics, University Hospital of Kinshasa, Kinshasa, DRC.
Faculty of Medicine, University of Kinshasa, Kinshasa, DRC.
Acta Paediatr. 2015 Dec;104(12):1274-7. doi: 10.1111/apa.13049. Epub 2015 Oct 6.
There is very little data on acute kidney injury in neonates in Africa. The aim of this study was to describe the frequency of acute kidney injury and the outcome in neonates admitted to hospital for asphyxia in the Democratic Republic of Congo.
A descriptive study was conducted in the country's capital Kinshasa. Acute kidney injury was diagnosed within three days of life when the creatinine clearance was ≤16 mL/min/1.73 m².
Acute kidney injury occurred in 54.3% of the 35 neonates with severe perinatal asphyxia and 31.4% of the 35 neonates with moderate perinatal asphyxia, and this rate was higher than the prevalence reported in Western countries. Prerenal acute kidney injury occurred in 12 (40%) of the 30 neonates with acute kidney injury. The frequency of oliguria was significantly higher in neonates with severe perinatal asphyxia than moderate perinatal asphyxia (73.7% vs. 45.5%), and mortality was also higher in neonates with severe rather than moderate perinatal asphyxia (57.9% vs. 36.4%).
The prevalence of acute kidney injury was higher in asphyxiated patients in the Democratic Republic of Congo than in Western countries. It was also higher in neonates with severe rather than moderate perinatal asphyxia.
非洲新生儿急性肾损伤的数据非常少。本研究的目的是描述刚果民主共和国因窒息入院的新生儿急性肾损伤的发生率及转归情况。
在该国首都金沙萨开展了一项描述性研究。当肌酐清除率≤16 mL/（min·1.73 m²）时，在出生后三天内诊断为急性肾损伤。
35例重度围产期窒息新生儿中，54.3%发生急性肾损伤；35例中度围产期窒息新生儿中，31.4%发生急性肾损伤，该发生率高于西方国家报道的患病率。30例急性肾损伤新生儿中，12例（40%）发生肾前性急性肾损伤。重度围产期窒息新生儿的少尿发生率显著高于中度围产期窒息新生儿（73.7%对45.5%），重度围产期窒息新生儿的死亡率也高于中度围产期窒息新生儿（57.9%对36.4%）。
刚果民主共和国窒息患者的急性肾损伤患病率高于西方国家。重度围产期窒息新生儿的急性肾损伤患病率也高于中度围产期窒息新生儿。
