Institut für Anorganische Chemie, Georg-August-Universität, Tammannstrasse 4, 37077 Göttingen (Germany).
Angew Chem Int Ed Engl. 2015 Jun 8;54(24):6994-8. doi: 10.1002/anie.201502576. Epub 2015 May 27.
Lithium diisopropyl amide (LDA) is a very prominent reagent that plays a key role in organic synthesis, serving as a base par excellence for a broad range of deprotonation reactions. However, the state of aggregation in solution in the absence of donor bases was unclear. In this paper we solved this problem by employing DOSY NMR experiments based on a newly elaborated external calibration curve (ECC) approach with normalized diffusion coefficients.
二异丙基胺锂（LDA）是一种非常重要的试剂，在有机合成中起着关键作用，是广泛的去质子化反应的卓越碱。然而，在没有给电子碱的情况下，其在溶液中的聚集状态尚不清楚。在本文中，我们通过使用基于新开发的外部校准曲线（ECC）方法的 DOSY NMR 实验，并采用归一化扩散系数来解决这个问题。
