Naidu P Seetham, Kolita Sinki, Sharma Meenakshi, Bhuyan Pulak J
J Org Chem. 2015 Jun 19;80(12):6381-90. doi: 10.1021/acs.joc.5b00533. Epub 2015 Jun 5.
A simple and efficient method for the synthesis of highly functionalized indoles and biindoles was developed. In the reaction protocol, three components were used in one pot and products were obtained in high yield in an easy workup procedure. The reaction occurred via initial reductive alkylation of α-keto imines, followed by a cyclization process in the presence of PTSA/FeCl3 as catalyst.
开发了一种简单有效的方法来合成高度官能化的吲哚和双吲哚。在该反应方案中，三种组分在一锅反应中使用，并且通过简便的后处理程序以高产率获得产物。反应通过α-酮亚胺的初始还原烷基化进行，随后在对甲苯磺酸/三氯化铁作为催化剂存在下进行环化过程。
