Geng Jia, Guo Wan-Liang, Zhang Xue-Lan
Clinical Laboratory, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215003, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2015 May;17(5):482-6.
To investigate the prevalence of respiratory syncytial virus (RSV) infection in hospitalized children and the relationship between the prevalence and the climate change in Suzhou, China.
A total of 42 664 nasopharyngeal secretions from hospitalized children with acute respiratory infection at the Suzhou Children's Hospital were screened for RSV antigens using direct immunofluorescence. Monthly meteorological data (mean monthly air temperature, monthly relative humidity, monthly rainfall, total monthly sunshine duration, and mean monthly wind velocity) in Suzhou between 2001 and 2011 were collected. The correlations between RSV detection rate and climatic factors were evaluated using correlation and stepwise regression analysis.
The annual RSV infection rate in hospitalized children with respiratory infection in the Suzhou Children's Hospital varied between 11.85% and 27.30% from 2001 to 2011. In the 9 epidemic seasons, each spanning from November to April of the next year, from 2001 to 2010, the RSV detection rates were 40.75%, 22.72%, 39.93%, 27.37%, 42.71%, 21.28%, 38.57%, 19.86%, and 29.73%, respectively; there were significant differences in the detection rate between the epidemic seasons. The monthly RSV detection rate was negatively correlated with mean monthly air temperature, total monthly sunshine duration, monthly rainfall, monthly relative humidity, and mean monthly wind velocity (P<0.05). Stepwise regression analysis showed that mean monthly air temperature fitted into a linear model (R(2)=0.64, P<0.01).
From 2001 to 2011, RSV infection in Suzhou was predominantly prevalent between November and April of the next year. As a whole, the infection rate of RSV reached a peak every other year. Air temperature played an important role in the epidemics of RSV infection in Suzhou.
调查中国苏州住院儿童呼吸道合胞病毒（RSV）感染的患病率及其与气候变化的关系。
采用直接免疫荧光法对苏州儿童医院42664例急性呼吸道感染住院儿童的鼻咽分泌物进行RSV抗原筛查。收集苏州2001年至2011年的月气象数据（月平均气温、月相对湿度、月降雨量、月总日照时长和月平均风速）。采用相关性和逐步回归分析评估RSV检出率与气候因素之间的相关性。
2001年至2011年，苏州儿童医院呼吸道感染住院儿童的年度RSV感染率在11.85%至27.30%之间波动。在2001年至2010年的9个流行季节（每个流行季节从11月持续至次年4月）中，RSV检出率分别为40.75%、22.72%、39.93%、27.37%、42.71%、21.28%、38.57%、19.86%和29.73%；流行季节之间的检出率存在显著差异。每月RSV检出率与月平均气温、月总日照时长、月降雨量、月相对湿度和月平均风速呈负相关（P<0.05）。逐步回归分析表明，月平均气温符合线性模型（R(2)=0.64，P<0.01）。
2001年至2011年，苏州RSV感染主要在11月至次年4月流行。总体而言，RSV感染率每隔一年达到峰值。气温在苏州RSV感染流行中起重要作用。
