Solodky V A, Pavlov A Yu, Panshin G A, Gafanov R A, Fastovets S V, Isaev T K
Vopr Onkol. 2015;61(1):31-3.
To relieve pain associated with multiple bone metastases radiopharmaceutical method of treatment is of great importance--the use of beta-emission isotope of strontium chloride-89 (metastron). Passing through the human skeletal system, strontium-89 accumulates in areas of high mineral density, which is it typical for osteoblastic metastases. In our institution in the frames of a randomized trial in 90 patients with metastatic hormone-resistant prostate cancer it was carried out systemic radiotherapy with strontium-89 chloride as a stage of complex treatment. Stabilization of pain syndrome during treatment was 72,7% and its progression was noted in 27,3% cases. Radiopharmaceutical therapy is well tolerated and can be used as a stage in complex treatment of patients with hormone-resistant prostate cancer.
为缓解与多发性骨转移相关的疼痛，放射性药物治疗方法非常重要——使用氯化锶 - 89（美他生）的β发射同位素。锶 - 89穿过人体骨骼系统，积聚在高矿物质密度区域，这是成骨细胞转移的典型特征。在我们机构进行的一项针对90例转移性激素抵抗性前列腺癌患者的随机试验中，采用氯化锶 - 89进行全身放疗作为综合治疗的一个阶段。治疗期间疼痛综合征的稳定率为72.7%，27.3%的病例出现病情进展。放射性药物治疗耐受性良好，可作为激素抵抗性前列腺癌患者综合治疗的一个阶段。
