[The mechanism of action of pachycarpine on the nicotinic cholinoreceptors of sympathetic ganglion neurons in the rat].

The mechanism of the pachycarpine action was studied in isolated superior cervical ganglion of rat using the patch-clamp method in the whole-cell recording mode. Action of the pachycarpine is not potential-dependent in the membrane potential range from +30 to -50 mV, the blockade increases during hyperpolarization of the membrane (-50-90 mV). Changes in the "dose-effect" dependence show that the blocking of nicotinic acetylcholine receptors is competitive both within the potential-dependent interval and within the potential-independent one.