海藻酸诱导的癫痫发作对大鼠组织微量元素浓度的影响。

Effect of kainate-induced seizures on tissue trace element concentrations in the rat.

作者信息

Carl G F, Critchfield J W, Thompson J L, McGinnis L S, Wheeler G A, Gallagher B B, Holmes G L, Hurley L S, Keen C L

机构信息

Department of Neurology, Medical College of Georgia, Augusta 30912.

出版信息

Neuroscience. 1989;33(1):223-7. doi: 10.1016/0306-4522(89)90323-0.

DOI:10.1016/0306-4522(89)90323-0

PMID:2601857

Abstract

It has been shown that epileptics have lower mean blood concentration of manganese than do controls but the cause of this abnormality has not been determined. In order to investigate the effects of seizures on manganese distribution in the body, rats were treated with kainic acid to produce spontaneous seizures which were quantitated for number and severity. Manganese, zinc, copper and iron concentrations were determined in blood, brain, liver, heart and kidney. Kainate-treated animals ate more food but gained less weight than controls. Liver and kidney manganese concentrations were significantly higher in kainate-treated animals than in controls. Blood manganese concentration showed a significant negative correlation with seizure index while heart manganese concentration showed a significant positive correlation with seizure index. None of the other trace elements showed a significant correlation between trace element concentration and seizure index in any of the tissues, although iron concentration was lower in brain and copper concentration was lower in kidney of kainate-treated animals than in their appropriate controls. These data show that manganese concentrations are generally elevated in tissues of kainate-treated animals. This increased manganese concentration may be related to the increased energy demand of these animals.

摘要

研究表明，癫痫患者体内锰的平均血浓度低于对照组，但这种异常现象的原因尚未确定。为了研究癫痫发作对体内锰分布的影响，用 kainic 酸处理大鼠以引发自发性癫痫发作，并对发作的次数和严重程度进行定量。测定了血液、大脑、肝脏、心脏和肾脏中锰、锌、铜和铁的浓度。用 kainate 处理的动物比对照组吃更多的食物，但体重增加较少。用 kainate 处理的动物肝脏和肾脏中的锰浓度显著高于对照组。血锰浓度与癫痫发作指数呈显著负相关，而心脏锰浓度与癫痫发作指数呈显著正相关。尽管用 kainate 处理的动物大脑中的铁浓度低于相应对照组，肾脏中的铜浓度也低于相应对照组，但在任何组织中，其他微量元素的浓度与癫痫发作指数之间均未显示出显著相关性。这些数据表明，用 kainate 处理的动物组织中锰浓度普遍升高。这种锰浓度的增加可能与这些动物能量需求的增加有关。