Carl G F, Critchfield J W, Thompson J L, Holmes G L, Gallagher B B, Keen C L
Department of Neurology, Medical College of Georgia, Augusta.
Epilepsia. 1990 May-Jun;31(3):247-52. doi: 10.1111/j.1528-1157.1990.tb05372.x.
Since trace element abnormalities have been found in the human epileptic population, trace element concentrations were determined in blood and tissues of genetically epilepsy-prone rats both exposed to an unexposed to seizure-inducing stimuli and in genetically related epilepsy-resistant rats. Half of the epilepsy-prone group were exposed to seizure-inducing sound twice daily for 3 weeks. Food intake and weight gain were monitored for each animal. Genetically epilepsy prone rats with induced seizures consumed significantly less food and gained less weight than did the epilepsy resistant group. Seizure prone rats without seizures consumed the same amount of food as the resistant rats but gained less weight than the resistant strain but more than the seizure-induced animals. Epilepsy-prone animals had significantly altered trace element concentrations in tissues as compared with the resistant animals independent of seizure induction. Brain and liver iron, liver copper, and brain and heart manganese levels were all significantly lower in the seizure-prone rats as compared with the seizure-resistant rats. In the seizure-prone rats, induction of seizures resulted in an increase in brain and heart zinc levels and a decrease in whole blood manganese levels. These results demonstrate that both genetic factors relevant to susceptibility to seizures and the seizures themselves are associated with changes in trace element concentrations.
由于在人类癫痫患者群体中发现了微量元素异常，因此测定了暴露于和未暴露于诱发癫痫刺激的遗传性癫痫易感大鼠以及与其基因相关的癫痫抗性大鼠的血液和组织中的微量元素浓度。将癫痫易感组的一半大鼠每天两次暴露于诱发癫痫的声音中，持续3周。监测每只动物的食物摄入量和体重增加情况。诱发癫痫的遗传性癫痫易感大鼠比癫痫抗性组消耗的食物明显更少，体重增加也更少。未发生癫痫的癫痫易感大鼠消耗的食物量与抗性大鼠相同，但体重增加比抗性品系少，但比诱发癫痫的动物多。与抗性动物相比，癫痫易感动物组织中的微量元素浓度发生了显著变化，且与癫痫诱发无关。与癫痫抗性大鼠相比，癫痫易感大鼠的脑和肝脏铁、肝脏铜以及脑和心脏锰水平均显著降低。在癫痫易感大鼠中，癫痫诱发导致脑和心脏锌水平升高以及全血锰水平降低。这些结果表明，与癫痫易感性相关的遗传因素以及癫痫本身都与微量元素浓度的变化有关。
