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你想要点什么？个体修复能力对癌症基因毒性疗法疗效的影响。第二部分——抗癌治疗疗效评估中个体修复能力生物标志物的信息内容和有效性。

What's your poison? Impact of individual repair capacity on the outcomes of genotoxic therapies in cancer. Part II - information content and validity of biomarkers for individual repair capacity in the assessment of outcomes of anticancer therapy.

作者信息

Petkova Rumena, Chelenkova Pavlina, Georgieva Elena, Chakarov Stoian

机构信息

Scientific Technological Service (STS) , Sofia , Bulgaria.

Sofia University "St. Kliment Ohridski", Faculty of Biology , Sofia , Bulgaria.

出版信息

Biotechnol Biotechnol Equip. 2014 Jan 2;28(1):2-7. doi: 10.1080/13102818.2014.902532.

DOI:10.1080/13102818.2014.902532
PMID:26019482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4433894/
Abstract

The individual variance in the efficiency of repair of damage induced by genotoxic therapies may be an important factor in the assessment of eligibility for different anticancer treatments, the outcomes of various treatments and the therapy-associated complications, including acute and delayed toxicity and acquired drug resistance. The second part of this paper analyses the currently available information about the possibilities of using experimentally obtained knowledge about individual repair capacity for the purposes of personalised medicine and healthcare.

摘要

基因毒性疗法所诱导损伤的修复效率存在个体差异，这可能是评估不同抗癌治疗的适用性、各种治疗的结果以及治疗相关并发症（包括急性和迟发性毒性以及获得性耐药）的一个重要因素。本文的第二部分分析了目前可用的信息，这些信息涉及利用关于个体修复能力的实验性知识来实现个性化医疗和保健的可能性。