Uitterlinden A G, Slagboom P E, Johnson T E, Vijg J
Department of Molecular Biology, TNO Institute for Experimental Gerontology, Rijswijk, The Netherlands.
Nucleic Acids Res. 1989 Dec 11;17(23):9527-30. doi: 10.1093/nar/17.23.9527.
Many species have been shown to contain tandemly repeated short sequence DNA known as minisatellites and simple sequence motifs. Due to allelic variation in the copy number of the repeat unit these loci are usually highly polymorphic. Here we demonstrate the presence of sequences in the genome of the nematode Caenorhabditis elegans which are homologous to two sets of short sequence DNA. However, when two independent strains were compared no polymorphism for these sequences could be detected.
许多物种已被证明含有串联重复的短序列DNA,即微卫星和简单序列基序。由于重复单元拷贝数的等位基因变异,这些位点通常具有高度多态性。在这里,我们证明了线虫秀丽隐杆线虫基因组中存在与两组短序列DNA同源的序列。然而,当比较两个独立的菌株时,未检测到这些序列的多态性。