Trombini Amanda B, Franco Claudinéia Cs, Miranda Rosiane A, de Oliveira Júlio C, Barella Luiz F, Prates Kelly V, de Souza Aline A, Pavanello Audrei, Malta Ananda, Almeida Douglas L, Tófolo Laize P, Rigo Kesia P, Ribeiro Tatiane As, Fabricio Gabriel S, de Sant'Anna Juliane R, Castro-Prado Marialba Aa, de Souza Helenir Medri, de Morais Hely, Mathias Paulo Cf
a Laboratory of Secretion Cell Biology; Department of Biotechnology, Genetics and Cell Biology; State University of Maringá ; Maringá, Brazil.
Cancer Biol Ther. 2015;16(6):958-64. doi: 10.4161/15384047.2014.962968. Epub 2015 May 29.
It is known that antidiabetic drug metformin, which is used worldwide, has anti-cancer effects and can be used to prevent cancer growth. We tested the hypothesis that tumor cell growth can be inhibited by early treatment with metformin. For this purpose, adult rats chronically treated with metformin in adolescence or in adulthood were inoculated with Walker 256 carcinoma cells. Adult rats that were treated with metformin during adolescence presented inhibition of tumor growth, and animals that were treated during adult life did not demonstrate any changes in tumor growth. Although we do not have data to disclose a molecular mechanism to the preventive metformin effect, we present, for the first time, results showing that cancer growth in adult life is dependent on early life intervention, thus supporting a new therapeutic prevention for cancer.
众所周知,全球广泛使用的抗糖尿病药物二甲双胍具有抗癌作用,可用于预防癌症生长。我们验证了早期使用二甲双胍治疗可抑制肿瘤细胞生长这一假设。为此,将在青春期或成年期长期接受二甲双胍治疗的成年大鼠接种Walker 256癌细胞。青春期接受二甲双胍治疗的成年大鼠肿瘤生长受到抑制,而成年期接受治疗的动物肿瘤生长未出现任何变化。尽管我们尚无数据揭示二甲双胍预防作用的分子机制,但我们首次展示的结果表明,成年期的癌症生长取决于生命早期的干预,从而支持了一种新的癌症治疗性预防方法。