Clarke Sharon E, Saranathan Manojkumar, Rettmann Dan W, Hargreaves Brian A, Vasanawala Shreyas S
.
Clin Invest Med. 2015 May 31;38(3):E90-9. doi: 10.25011/cim.v38i3.22704.
To determine the reliability of arterial phase capture and evaluate hypervascular lesion contrast kinetics with a combined view-sharing and parallel imaging dynamic contrast-enhanced acquisition, DIfferential Sub-sampling with Cartesian Ordering (DISCO), in patients with known chronic liver disease.
A retrospective review of 3T MR images from 26 patients with known chronic liver disease referred for hepatocellular carcinoma surveillance or post-treatment follow up was performed. After administration of a gadolinium-based contrast agent, a multiphasic acquisition was obtained in a 28 s breath-hold, from which seven sequential post-contrast image volumes were reconstructed.
The late arterial phase was successfully captured in all cases (26/26, 95% CI 87-100%). Images obtained 26 s post-injection had the highest frequency of late arterial phase capture (20/26) and lesion detection (23/26) of any individual post-contrast time; however, the multiphasic data resulted in a significantly higher frequency of late arterial phase capture (26/26, p=0.03) and a higher relative contrast (5.37+/-0.97 versus 7.10+/-0.98, p < 0.01).
Multiphasic acquisition with combined view-sharing and parallel imaging reliably captures the late arterial phase and provides sufficient temporal resolution to characterize hepatic lesion contrast kinetics in patients with chronic liver disease while maintaining high spatial resolution.
利用一种结合视图共享和平行成像的动态对比增强采集方法——笛卡尔排序差分采样（DISCO），确定已知慢性肝病患者动脉期采集的可靠性，并评估高血运病变的对比剂动力学。
对26例已知慢性肝病患者的3T磁共振图像进行回顾性分析，这些患者因肝细胞癌监测或治疗后随访前来就诊。静脉注射钆基对比剂后，在28秒屏气状态下进行多期采集，重建出七组连续的对比剂注射后图像容积。
所有病例均成功采集到延迟动脉期图像（26/26，95%可信区间87 - 100%）。注射后26秒获得的图像在所有对比剂注射后各时间点中，延迟动脉期采集频率（20/26）和病变检出率（23/26）最高；然而，多期数据的延迟动脉期采集频率显著更高（26/26，p = 0.03），相对对比值也更高（分别为5.37±0.97和7.10±0.98，p < 0.01）。
结合视图共享和平行成像的多期采集能够可靠地采集延迟动脉期图像，并提供足够的时间分辨率来描述慢性肝病患者肝脏病变的对比剂动力学，同时保持较高的空间分辨率。
