Carrilho F J, Queiroz M L, da Silva L C, da Fonseca L E, Granato C, Oba I, Obara L
Rev Inst Med Trop Sao Paulo. 1989 Mar-Apr;31(2):91-4. doi: 10.1590/s0036-46651989000200005.
Schedule for vaccination against HBV infection has usually been based on three separate injections of 20 mcg of the vaccine by intramuscular route. One of the main shortcomings to its use in large scale programs has been its high cost. Ninety out of 300 health workers were submitted to three injections of 2 mcg of plasma-derived vaccine (PDV) by intradermal (ID) route on days 0, 30, and 180. Anti-HBs was detected in 74 (82.2%) after the second dose and in 80 (88.9%) after the third dose, a non-significant difference. However, levels above 10 times the cut-off were observed in 29 (32.2%) and 77 (85.5%), respectively (p less than 0.001). The results showed that a low-dose schedule is effective when used in health workers and should be tried with other risk groups.
乙型肝炎病毒（HBV）感染的疫苗接种计划通常是通过肌肉注射途径分三次单独注射20微克疫苗。其在大规模项目中使用的主要缺点之一是成本高昂。300名医护人员中有90人在第0、30和180天通过皮内（ID）途径接受了三次2微克血浆源性疫苗（PDV）注射。第二次注射后，74人（82.2%）检测到抗-HBs，第三次注射后80人（88.9%）检测到抗-HBs，差异无统计学意义。然而，分别有29人（32.2%）和77人（85.5%）观察到高于临界值10倍的水平（p小于0.001）。结果表明，低剂量接种计划在医护人员中使用时是有效的，应该在其他风险群体中进行尝试。
