肥厚性梗阻性心肌病患者心肌细胞倍性的年龄相关特征
Age-Related Features of Cardiomyocyte Ploidy in Patients with Hypertrophic Obstructive Cardiomyopathy.
作者信息
Sukhacheva T V, Chudinovskikh Yu A, Eremeeva M V, Serov R A
机构信息
A. N. Bakulev Research Centre for Cardiovascular Surgery, Russian Academy of Sciences, Moscow, Russia,
出版信息
Bull Exp Biol Med. 2015 May;159(1):95-9. doi: 10.1007/s10517-015-2899-4. Epub 2015 Jun 2.
Endomyocardial biopsy samples of the interventricular septum from patients with hypertrophic cardiomyopathy isolated during myectomy were examined. We revealed significant variability of cardiomyocyte ploidy (from 2.9c to 13.5c) that directly correlated with myocyte size; the maximum ploidy was found in young patients. Ultrastructural signs of increased contractile and synthetic activity of cells were observed in patients with high DNA content in cardiomyocytes.
对在心肌切除术中分离出的肥厚型心肌病患者的室间隔心内膜心肌活检样本进行了检查。我们发现心肌细胞倍性存在显著差异（从2.9c到13.5c），且与心肌细胞大小直接相关；最大倍性见于年轻患者。在心肌细胞中DNA含量高的患者中观察到细胞收缩和合成活性增加的超微结构特征。
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