Li Z P, Tang C S, Su J Y
Sheng Li Xue Bao. 1989 Oct;41(5):470-5.
Rat's Ca-resistant ventricular myocytes and reconstituted liposomes of canine cardiac sarcolemma were used in analysing factors affecting Na(+)-Ca2+ exchange system. Decrease in extracellular (extravesicular) Na+ or increase in intracellular Na+ by inhibition of the Za(+)-K(+)-ATPase with ouabain stimulated the Na(+)-Ca2+ exchange. Mn2+, an antagonist of Na(+)-Ca2+ exchange, dose-dependently inhibited the Na(+)-dependent Ca2+ uptake. However, verapamil had no effect on it. Arachidonic acid and lipid peroxides caused by incubation with-H2O2 significantly stimulated Na(+)-Ca2+ exchange in a dose-dependent fashion.
利用大鼠抗钙心室肌细胞和犬心肌肌膜重构脂质体分析影响钠钙交换系统的因素。用哇巴因抑制钠钾ATP酶降低细胞外（囊泡外）钠离子浓度或增加细胞内钠离子浓度可刺激钠钙交换。锰离子作为钠钙交换的拮抗剂，呈剂量依赖性抑制钠依赖性钙摄取。然而，维拉帕米对此无作用。与过氧化氢孵育产生的花生四烯酸和脂质过氧化物以剂量依赖性方式显著刺激钠钙交换。
