Beurskens Frank J, van Schaarenburg Rosanne A, Trouw Leendert A
Genmab, Utrecht, The Netherlands.
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Mol Immunol. 2015 Nov;68(1):6-13. doi: 10.1016/j.molimm.2015.05.010. Epub 2015 May 29.
The complement system has long been known for its role in combating infections. More recently the complement system is becoming increasingly appreciated for its role in processes that range from waste transport, immune tolerance and shaping of the adaptive immune response. Antibodies represent the humoral part of the adaptive immune response and the complement system interacts with antibodies in several ways. Activated complement fragments impact on the production of antibodies, the complement system gets activated by antibodies and complement proteins can be the target of (auto)antibodies. In this review, written to celebrate the contributions of Prof. Dr. M.R. Daha to the field of immunology and especially complement, we will focus on C1q and its various interactions with antibodies. We will specifically focus on the mechanisms by which C1q will interact with monomeric IgG versus polymerized IgG and fluid-phase IgM versus solid-phase IgM. In addition in this review we will discuss in detail how C1q itself is targeted by autoantibodies and how these autoantibodies are currently considered to play a role in human disease.
补体系统长期以来因其在对抗感染中的作用而闻名。最近，补体系统在从废物运输、免疫耐受到适应性免疫反应形成等一系列过程中的作用越来越受到重视。抗体代表适应性免疫反应的体液部分，补体系统以多种方式与抗体相互作用。活化的补体片段影响抗体的产生，补体系统被抗体激活，补体蛋白可以成为（自身）抗体的靶标。在这篇为庆祝M.R. Daha教授对免疫学领域尤其是补体领域的贡献而撰写的综述中，我们将重点关注C1q及其与抗体的各种相互作用。我们将特别关注C1q与单体IgG、聚合IgG、液相IgM和固相IgM相互作用的机制。此外，在本综述中，我们将详细讨论C1q自身如何成为自身抗体的靶标，以及目前认为这些自身抗体如何在人类疾病中发挥作用。
