Bespalov V G, Belyaeva O A, Kireeva G S, Senchik K Yu, Stukov A N, Belyaev A M
Laboratory of Cancer Chemotherapeutic Prevention and Oncopharmacology, N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia,
Bull Exp Biol Med. 2015 May;159(1):81-4. doi: 10.1007/s10517-015-2895-8. Epub 2015 Jun 3.
Experimental perfusion system and technology for normothermic and hyperthermic intraperitoneal chemoperfusion are developed for the treatment of abdominal carcinomatosis in rats with transplanted ovarian cancer. MTD of cisplatin in normothermic intraperitoneal chemoperfusion and hyperthermic perfusion are 40 and 20 mg/kg, i.e. by 10- and 5-fold higher than the dose of this cytostatic for routine intraperitoneal injection. Normothermic intraperitoneal chemoperfusion with cisplatin increases median survival time by 200% (p=0.039) in comparison with intraperitoneal injection.
开发了用于常温及热腹腔内化疗灌注的实验灌注系统和技术，用于治疗移植性卵巢癌大鼠的腹腔癌。顺铂在常温腹腔内化疗灌注和热灌注中的最大耐受剂量分别为40和20mg/kg，即比这种细胞抑制剂常规腹腔注射剂量高10倍和5倍。与腹腔注射相比，顺铂常温腹腔内化疗灌注可使中位生存时间增加200%（p=0.039）。
