Hernández-Ramírez Daniel, Esparza-Pérez Mario A, Ramirez-Garcialuna José L, Arguello J Rafael, Mandeville Peter B, Noyola Daniel E, García-Sepúlveda Christian A
Laboratorio de Genómica Viral y Humana, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, Ave. Venustiano Carranza #2405, Col. Filtros Las Lomas, 78210, San Luis Potosí, SLP, Mexico.
Immunogenetics. 2015 Aug;67(8):413-24. doi: 10.1007/s00251-015-0848-z. Epub 2015 Jun 3.
Certain genotypic combinations of killer-cell immunoglobulin-like receptors (KIR) and human leukocyte antigens (HLA) have been associated with favourable outcomes after exposure to human immunodeficiency virus in Caucasoid and African populations. Human immunodeficiency virus (HIV) infection is characterized by a rapid exhaustion of CD4 cells, which results in impaired cellular immunity. During this early phase of infection, it is thought that the natural killer (NK) cells represent the main effector arm of the host immune response to HIV. This study investigates whether KIR and HLA factors are associated to CD4 T cell numbers after HIV infection in Mexican mestizos as assessed at the time of initial medical evaluation and subsequent clinical follow-up. KIR and HLA-B gene carrier frequency differences were compared between groups of patients stratified by CD4 T cell numbers as assessed during their first medical evaluation (a point in time at which all patients were anti-retroviral therapy naïve). In addition, the influence that these genetic factors have on averaged historical CD4 cell counts in patients subjected to follow-up (mostly therapy-experienced) was also evaluated. Our results suggest a protective role for the HLA-Bw4 and KIR3D + Bw4 combination in both therapy-naïve and therapy-experienced patients. This report furthers our understanding on the way that immune genes modulate HIV disease progression in less-studied human populations such as the Mexican mestizos with a special focus on CD4 T cell number and behaviour.
在高加索人和非洲人群中，杀伤细胞免疫球蛋白样受体（KIR）和人类白细胞抗原（HLA）的某些基因型组合与接触人类免疫缺陷病毒后的良好预后相关。人类免疫缺陷病毒（HIV）感染的特征是CD4细胞迅速耗竭，这导致细胞免疫受损。在感染的早期阶段，自然杀伤（NK）细胞被认为是宿主对HIV免疫反应的主要效应臂。本研究调查了在墨西哥混血人群中，初次医学评估和随后的临床随访时评估的HIV感染后KIR和HLA因素是否与CD4 T细胞数量相关。比较了根据初次医学评估时（所有患者均未接受抗逆转录病毒治疗的时间点）评估的CD4 T细胞数量分层的患者组之间的KIR和HLA-B基因携带者频率差异。此外，还评估了这些遗传因素对接受随访的患者（大多数有治疗经验）的平均历史CD4细胞计数的影响。我们的结果表明，HLA-Bw4和KIR3D + Bw4组合在未接受治疗和有治疗经验的患者中均具有保护作用。本报告进一步加深了我们对免疫基因在墨西哥混血等研究较少的人群中调节HIV疾病进展方式的理解，特别关注CD4 T细胞数量和行为。
