β-内酰胺/β-内酰胺酶抑制剂和厄他培南在拟杆菌菌血症中耐药的危险因素。
Risk Factors for Resistance to β-Lactam/β-Lactamase Inhibitors and Ertapenem in Bacteroides Bacteremia.
机构信息
Department of Pharmacy, The Johns Hopkins Hospital, Baltimore, Maryland, USA
Department of Pharmacy, The Johns Hopkins Hospital, Baltimore, Maryland, USA.
出版信息
Antimicrob Agents Chemother. 2015 Aug;59(8):5049-51. doi: 10.1128/AAC.00046-15. Epub 2015 Jun 1.
Abstract
The objective of this study was to determine risk factors for the development of resistance to β-lactams/β-lactamase inhibitors (βL/βLIs) and ertapenem among Bacteroides species bacteremia. We conducted a retrospective case-control study of 101 adult patients with Bacteroides species bacteremia at a 1,051-bed tertiary care medical center. The duration of exposure to βL/βLIs (odds ratio [OR], 1.25; 95% confidence interval [CI], 1.08 to 2.31) was the only independent risk factor for resistance.
摘要
本研究旨在确定脆弱拟杆菌属菌血症患者对β-内酰胺类/β-内酰胺酶抑制剂（βL/βLIs）和厄他培南产生耐药的风险因素。我们对一家拥有 1051 张床位的三级保健医疗中心的 101 例成年脆弱拟杆菌属菌血症患者进行了回顾性病例对照研究。βL/βLIs 的暴露时间（比值比[OR]，1.25；95%置信区间[CI]，1.08 至 2.31）是唯一的独立耐药风险因素。
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