分枝杆菌万古霉素敏感性增加：一种鉴定抗多药耐药分枝杆菌协同活性的新方法。
Increased Vancomycin Susceptibility in Mycobacteria: a New Approach To Identify Synergistic Activity against Multidrug-Resistant Mycobacteria.
机构信息
Scientific Institute of Public Health (WIV-ISP), Operational Direction of Communicable and Infectious Diseases, Brussels, Belgium.
Université Libre de Bruxelles (ULB), Unit of Pharmaceutical Microbiology and Hygiene, Brussels, Belgium.
出版信息
Antimicrob Agents Chemother. 2015 Aug;59(8):5057-60. doi: 10.1128/AAC.04856-14. Epub 2015 Jun 1.
Abstract
Mycobacterium tuberculosis is wrapped in complex waxes, impermeable to most antibiotics. Comparing Mycobacterium bovis BCG and M. tuberculosis mutants that lack phthiocerol dimycocerosates (PDIM) and/or phenolic glycolipids with wild-type strains, we observed that glycopeptides strongly inhibited PDIM-deprived mycobacteria. Vancomycin together with a drug targeting lipid synthesis inhibited multidrug-resistant (MDR) and extensively drug-resistant (XDR) clinical isolates. Our study puts glycopeptides in the pipeline of potential antituberculosis (TB) agents and might provide a new antimycobacterial drug-screening strategy.
摘要
结核分枝杆菌被复杂的蜡质包裹，大多数抗生素都无法穿透。我们比较了缺乏分枝菌酸二分枝菌酸酯（PDIM）和/或酚甘油酯的牛分枝杆菌卡介苗和结核分枝杆菌突变体与野生型菌株，观察到糖肽强烈抑制了缺乏 PDIM 的分枝杆菌。万古霉素与针对脂质合成的药物联合抑制了耐多药（MDR）和广泛耐药（XDR）的临床分离株。我们的研究将糖肽纳入潜在抗结核（TB）药物的研发管道，可能为新的抗分枝杆菌药物筛选策略提供了依据。
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