Klein L, Ailes N, Fackelman G E, Kellon E, Rosenberg H
Department of Clinical Studies, University of Pennsylvania School of Veterinary Medicine, New Bolton Center 19348.
Vet Surg. 1989 Nov-Dec;18(6):479-82. doi: 10.1111/j.1532-950x.1990.tb01131.x.
Signs of malignant hyperthermia, including progressive increases in PaCO2, skin temperature and heart rate, and elevated serum levels of potassium, inorganic phosphate, and creatine kinase, were identified in a halothane-anesthetized horse. Treatment was discontinuing halothane administration, applying ice and cold fluids, and hyperventilating with 100% oxygen. After an initial recovery, bilateral hindlimb myopathy and pigmenturia developed. The myopathy resolved after treatment with oral dantrolene, IV fluids, and hydrocortisone. Results of caffeine-halothane challenge, using semimembranosus muscle collected 2 weeks after the episode, were considered within normal limits for horses. The intraoperative abnormalities were evidently predictive of postanesthetic myopathy but the cause in this horse remained unclear.
在一匹氟烷麻醉的马身上发现了恶性高热的迹象，包括动脉血二氧化碳分压（PaCO2）、皮肤温度和心率逐渐升高，以及血清钾、无机磷和肌酸激酶水平升高。治疗方法是停止使用氟烷，冰敷并输注冷液体，并用100%氧气进行过度通气。在最初恢复后，出现了双侧后肢肌病和血红蛋白尿。口服丹曲林、静脉输液和氢化可的松治疗后，肌病得到缓解。使用发作后2周采集的半膜肌进行咖啡因-氟烷激发试验的结果被认为在马的正常范围内。术中异常显然可预测麻醉后肌病，但这匹马的病因仍不清楚。
