Wang Xuefeng, Jin Jing, Chen Rong
Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Expert Rev Neurother. 2015 Jun;15(6):639-54. doi: 10.1586/14737175.2015.1045881.
Status epilepticus (SE) is a common neurological emergent disease with high mortality and disability rates. Rapidly and effectively controlling seizures is key to saving the lives of patients and improving their prognoses. Traditional antiepileptic drugs for SE are ineffective in 30-40% of cases. In light of the diverse etiology and complex pathogenesis of SE, combination drug therapy for SE might be more conducive for the treatment of all patients because the combined use of drugs can produce synergistic effects via different mechanisms. This review summarizes combination drug therapies used for SE in animal experiments and clinical practice, the potential advantages of combination drug therapy and specific combination drug therapies using different antiepileptic drugs. The aim is to help researchers seek better treatments for early termination of SE.
癫痫持续状态（SE）是一种常见的神经系统急症，死亡率和致残率很高。迅速有效地控制癫痫发作是挽救患者生命和改善其预后的关键。传统的用于治疗SE的抗癫痫药物在30%-40%的病例中无效。鉴于SE病因多样且发病机制复杂，SE的联合药物治疗可能更有利于所有患者的治疗，因为联合用药可通过不同机制产生协同作用。本文综述了在动物实验和临床实践中用于SE的联合药物治疗、联合药物治疗的潜在优势以及使用不同抗癫痫药物的具体联合药物治疗。目的是帮助研究人员寻找更好的早期终止SE的治疗方法。
