Voskanyan K Sh, Vorozhtsova S V, Abrosimova A N, Mitsyn G V, Gaevskiy V N, Molokanov A G
Aviakosm Ekolog Med. 2014;48(5):21-6.
Effects of 7 Gy 60Co γ-radiation (acute and prolonged exposure), and combined exposure to 650 nm laser and γ-radiation on survival, peripheral blood, karyocyte count and mitotic index of bone marrow cells were studied in young C57BL/6 mice. All mice died following acute γ-irradiation at the dose rate of 1.14 Gy/min for 5 days or combined exposure for 11 days. Thirty percent survival from prolonged exposure to the dose rate of 0.027 Gy/min was observed after 19-day γ- and 38-day combined irradiation. Peripheral blood parameters did not differ significantly after acute and prolonged exposure; however, hyperchromemia was observed in mice after 24 hours of acute γ-irradiation. The count of mitoses per 1000 nucleus-containing BM cells evidenced that BM was virtually collapsed after 72 hours since the acute γ-exposure. It was demonstrated that laser can manage protection from a broad range of ionizing radiation doses and mitigate the adverse effects of equally acute and prolonged radiation exposure.
研究了7 Gy 60Co γ射线辐射（急性和长期暴露）以及650 nm激光与γ射线联合暴露对年轻C57BL/6小鼠的存活率、外周血、骨髓细胞核细胞计数和有丝分裂指数的影响。所有小鼠在以1.14 Gy/min的剂量率进行5天急性γ射线照射或联合照射11天后死亡。在19天γ射线照射和38天联合照射后，观察到长期暴露于0.027 Gy/min剂量率下有30%的存活率。急性和长期暴露后外周血参数无显著差异；然而，急性γ射线照射24小时后小鼠出现高色素血症。每1000个含核骨髓细胞的有丝分裂计数表明，急性γ射线暴露72小时后骨髓几乎完全崩溃。结果表明，激光可以对广泛的电离辐射剂量起到保护作用，并减轻急性和长期辐射暴露的不良影响。
