Chen Jun, Yu Jin, He Qiang, Zhao Xiong, Sang Hongxun, Lei Wei, Wu Zixiang, Chen Jingyuan
Department of Occupational & Environmental Health and The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Xijing Hospital, Fourth Military Medical University 169 Changle West Road, Xi'an 710032, China ; Institute of Orthopaedics, Xijing Hospital, Fourth Military Medical University 169 Changle West Road, Xi'an 710032, China.
Department of Cardiovascular Medicine, Xijing Hospital, Fourth Military Medical University 169 Changle West Road, Xi'an 710032, China.
Am J Transl Res. 2015 Mar 15;7(3):548-57. eCollection 2015.
The aim of this study is to determine the feasibility and effectiveness of a novel injectable Porous Surface Modified Bioactive Bone Cement (PSMBBC) for vertebroplasty of aiding osteoporotic vertebrae in an osteoporosis model.
72 osteoporosis rabbits were randomly divided into three groups: the Polymethyl Methacrylate (PMMA) group, the PSMBBC group and the control group. PMMA and PSMBBC were administrated to osteoporotic vertebrae in vertebroplasty, respectively. The animals were sacrificed at 1w, 4w, 12w after the procedure. Micro-CT analysis, biomechanical tests and histological analysis were performed at each time point.
From 4 to 12 weeks after the implantation of bone cements, the bone volume fraction (BV/TV) of the PSMBBC group increased from 28.27 ± 1.69% to 38.43 ± 1.34%. However, the BV/TV of the PMMA group showed no significant difference after the implantation. At 4 weeks, direct contact between the bone and the bone cement was observed in the PSMBBC group. At 12 weeks, it was discovered that new intact bone trabecular was formed in PSMBBC group. Furthermore, the maximum compressive strength values of the PSMBBC group were significantly higher than those of the control group at each time point after implantation.
In summary, this study was the first investigation to evaluate the potential application of PSMBBC for vertebroplasty. RESULTS demonstrated its beneficial effects on the trabecular ingrowth of new bone and bone mineral density increase. With further validation, PSMBBC can become a valuable biomaterial for aiding osteoporotic vertebrae and usable bone cement applied in vertebroplasty.
本研究旨在确定一种新型可注射多孔表面改性生物活性骨水泥（PSMBBC）用于骨质疏松模型中辅助骨质疏松椎体椎体成形术的可行性和有效性。
将72只骨质疏松兔随机分为三组：聚甲基丙烯酸甲酯（PMMA）组、PSMBBC组和对照组。在椎体成形术中分别将PMMA和PSMBBC注入骨质疏松椎体。术后1周、4周、12周处死动物。在每个时间点进行微计算机断层扫描（Micro-CT）分析、生物力学测试和组织学分析。
骨水泥植入后4至12周，PSMBBC组的骨体积分数（BV/TV）从28.27±1.69%增加到38.43±1.34%。然而，PMMA组植入后BV/TV无显著差异。在4周时，PSMBBC组观察到骨与骨水泥之间直接接触。在12周时，发现PSMBBC组形成了新的完整骨小梁。此外，PSMBBC组在植入后各时间点的最大抗压强度值均显著高于对照组。
总之，本研究是首次评估PSMBBC在椎体成形术中潜在应用的研究。结果表明其对新骨小梁生长和骨密度增加具有有益作用。经过进一步验证，PSMBBC可成为辅助骨质疏松椎体的有价值生物材料和用于椎体成形术的可用骨水泥。
