Kelly Micah, Williams Richard, Aojula Anuriti, O'Neill Jenna, Trzińscka Zuzanna, Grover Liam, Scott Robert A H, Peacock Anna F A, Logan Ann, Stamboulis Artemis, de Cogan Felicity
School of Clinical and Experimental Medicine, University of Birmingham, United Kingdom.
School of Chemical Engineering, University of Birmingham, United Kingdom; NIHR SRMRC Trauma Centre, Queen Elizabeth Hospital, Birmingham, United Kingdom.
Mater Sci Eng C Mater Biol Appl. 2015 Sep;54:84-93. doi: 10.1016/j.msec.2015.04.021. Epub 2015 Apr 22.
Current processes for coating titanium implants with ceramics involve very high energy techniques with associated high cost and disadvantages such as heterogeneity of the coatings, phase transformations and inability to coat complex structures. In order to address the above problems, we propose a biomimetic hydroxyapatite coating process with the use of peptides that can bind both on titanium surfaces and hydroxyapatite. The peptides enabled homogeneous coating of a titanium surface with hydroxyapatite. The hydroxyapatite-peptide sandwich coating showed no adverse effects on cell number or collagen deposition. This makes the sandwich coated titanium a good candidate for titanium implants used in orthopaedics and dentistry.
目前用陶瓷为钛植入物涂层的工艺涉及非常高能量的技术，伴随着高成本以及诸如涂层不均匀、相变和无法为复杂结构涂层等缺点。为了解决上述问题，我们提出了一种仿生羟基磷灰石涂层工艺，该工艺使用能够同时结合钛表面和羟基磷灰石的肽。这些肽能够使羟基磷灰石在钛表面均匀涂层。羟基磷灰石 - 肽夹心涂层对细胞数量或胶原蛋白沉积没有不利影响。这使得夹心涂层钛成为用于骨科和牙科的钛植入物的良好候选材料。
