Org Lett. 2015 Jun 19;17(12):3066-9. doi: 10.1021/acs.orglett.5b01349. Epub 2015 Jun 5.
Computational analyses of the first catalytic asymmetric Fischer indolization (J. Am. Chem. Soc. 2011, 133, 18534) reveal that enantioselectivity arises from differences in hydrogen bonding and CH/π interactions between the substrate and catalyst in the operative transition states. This selectivity occurs despite strong π-stacking interactions that reduce the enantioselectivity.
对首例催化不对称 Fischer 吲哚化反应的计算分析（J. Am. Chem. Soc. 2011, 133, 18534）表明，手性选择性源于底物和催化剂在操作过渡态中氢键和 CH/π 相互作用的差异。尽管强 π-堆积相互作用会降低对映选择性，但仍存在这种选择性。
