Foldes R L, Bresnick E
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, 68105.
Biochem Pharmacol. 1989 Dec 15;38(24):4425-8. doi: 10.1016/0006-2952(89)90652-7.
The bovine pancreatic deoxyribonuclease I (DNAase I) hypersensitivity of the rat cytochrome P450IA1 gene was investigated. A nuclease-hypersensitive region was observed at approximately 3.2 to 5.1 kilobase pairs upstream of exon 1 in adult and fetal rat liver. This region did not necessarily correlate with gene expression following 3-methylcholanthrene induction, although it may determine the potential for inducibility of this gene.
对大鼠细胞色素P450IA1基因的牛胰腺脱氧核糖核酸酶I（DNA酶I）超敏感性进行了研究。在成年和胎鼠肝脏中，在外显子1上游约3.2至5.1千碱基对处观察到一个核酸酶超敏感区域。该区域不一定与3-甲基胆蒽诱导后的基因表达相关，尽管它可能决定该基因的诱导潜力。
