Kitamoto I, Nakayama M, Miyazaki C, Minami T, Kurokawa T, Ueda K
Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Pediatr Neurol. 1989 Nov-Dec;5(6):342-6. doi: 10.1016/0887-8994(89)90046-5.
We investigated 4 infants with aseptic meningitis, 4-38 days of age, by repeated electroencephalography (EEG), flash-visual evoked potentials (F-VEPs), and brainstem auditory evoked potentials. The patients all had mild, acute phases and favorable outcomes at 1-2 years of age. EEGs and F-VEPs obtained within 1 month after onset all were defined as abnormal. In 3 patients, EEG findings were normal 1-2 months after onset, while F-VEP findings were normal at 9-10 months. Brainstem auditory evoked potential findings were normal, except for 1 with otitis media. Evoked potentials suggested that subclinical brain damage, especially due to cortical lesions, persisted during the first year of life in these patients clinically diagnosed with "meningitis."
我们对4例年龄在4至38天的无菌性脑膜炎婴儿进行了反复的脑电图（EEG）、闪光视觉诱发电位（F-VEP）和脑干听觉诱发电位检查。这些患儿在急性期均症状轻微，1至2岁时预后良好。发病后1个月内进行的脑电图和闪光视觉诱发电位检查结果均为异常。3例患儿在发病后1至2个月时脑电图结果恢复正常，而闪光视觉诱发电位结果在9至10个月时恢复正常。除1例患有中耳炎外，脑干听觉诱发电位检查结果均正常。诱发电位提示，在这些临床诊断为“脑膜炎”的患儿中，亚临床脑损伤，尤其是皮质病变导致的损伤，在出生后的第一年持续存在。
