Gross V, Gnüchtel U, Martynova E R, Medvedev O S
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1989;12(2):37-42.
The influence of acute volume-salt loading on renal excretory function and hemodynamics was studied in urethane-anesthetized and conscious immobilized, spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats on osmotic diuresis. The SHR have been shown to response to the intravenous sodium chloride load with exaggerated natriuresis as compared with the WKY group. The increase in natriuresis in the SHR did not depend on diuresis changes but was due to the increased urinary sodium concentration. Blood pressure changes after sodium chloride load were greater in the WKY than in the SHR group, which may be associated with restricted responsiveness of the cardiovascular system in the SHR.
在氨基甲酸乙酯麻醉且清醒固定的自发性高血压大鼠（SHR）和正常血压的Wistar-Kyoto（WKY）大鼠中，研究了急性容量-盐负荷对渗透性利尿时肾排泄功能和血流动力学的影响。与WKY组相比，SHR对静脉注射氯化钠负荷的反应表现为排钠增加。SHR中排钠增加并不依赖于利尿变化，而是由于尿钠浓度升高。WKY组在氯化钠负荷后血压变化比SHR组更大，这可能与SHR心血管系统反应性受限有关。
