Dua Kamal, Sheshala Ravi, Al-Waeli Haider A, Gupta Gauarv, Chellappan Dinesh K
Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia.
Recent Pat Drug Deliv Formul. 2015;9(3):257-61. doi: 10.2174/1872211309666150608095106.
Natural products like plants and its components have been in use for treatment and cure of diseases all around the globe from ancient times much before the discovery of the current modern drugs. These substances from the nature are well known to contain components which have therapeutic properties and can also behave as precursors for the synthesis of potential drugs. The beneficial results from herbal drugs are well reported where their popularity in usage has increased across the globe. Subsequently developing countries are now recognizing the many positive advantages from their use which has engaged the expansion of R & D from herbal research. The flow on effect from this expansion has increased the awareness to develop new herbal products and the processes, throughout the entire world. Mouth washes and mouth rinses which have plant oils, plant components or extracts have generated particular attention. High prevalence of gingival inflammation and periodontal diseases, suggests majority of the patients practice inadequate plaque control. Of the currently available mouthwashes in the market, Chlorhexidine gluconate (CHX) has been investigated on a larger scale with much detail. CHX is associated with side effects like staining of teeth when used daily as well as the bitter taste of the mouthwash which leads to patient incompliance. The present research encompasses the antibacterial activity of extemporaneously prepared herbal mouthwash using natural herbs and therefore allows for the potential commercialization with in the herbal and pharmaceutical industries. Also, the present research article reviewed details of various existing patents of herbal mouthwashes which shows the trend of existing market and significance of emerging mouthwashes in both pharmaceutical and herbal industries. The antimicrobial activity of prepared mouthwashes was found to be effective against various strains of bacteria. It also suggests that the prepared herbal mouthwashes may provide an alternative to those containing chemical entities, with enhanced antimicrobial properties and better patient compliance.
自古以来，在现代药物发现之前，植物等天然产物就在全球范围内被用于治疗和治愈疾病。众所周知，这些来自大自然的物质含有具有治疗特性的成分，也可以作为合成潜在药物的前体。草药的有益效果已有充分报道，其在全球的使用普及率不断提高。随后，发展中国家现在认识到使用草药的诸多积极优势，这推动了草药研究研发的扩展。这种扩展的连锁反应提高了全世界开发新草药产品及其生产工艺的意识。含有植物油、植物成分或提取物的漱口水和口腔冲洗液受到了特别关注。牙龈炎症和牙周疾病的高发病率表明，大多数患者的牙菌斑控制不足。在市场上现有的漱口水产品中，葡萄糖酸氯己定（CHX）已经得到了更广泛、更详细的研究。CHX存在一些副作用，比如每日使用时会导致牙齿染色，以及漱口水的苦味会导致患者依从性差。本研究涵盖了使用天然草药临时制备的草药漱口水的抗菌活性，因此有望在草药和制药行业实现商业化。此外，本研究文章回顾了各种现有草药漱口水专利的细节，这些细节展示了现有市场的趋势以及新兴漱口水在制药和草药行业的重要性。研究发现，制备的漱口水对各种细菌菌株具有抗菌活性。这也表明，制备的草药漱口水可能为含有化学成分的漱口水提供一种替代方案，具有增强的抗菌性能和更好的患者依从性。
