胎儿期和哺乳期暴露于酒精会增加大鼠棕色脂肪组织的氧化能力。这与婴儿猝死综合征可能存在关联。
Foetal and lactational exposure to alcohol increases oxidative capacity of brown adipose tissue in the rat. A possible relationship to cot death.
作者信息
Huttunen P, Kortelainen M L, Hirvonen J
机构信息
Department of Forensic Medicine, University of Oulu, Finland.
出版信息
Br J Exp Pathol. 1989 Dec;70(6):691-5.
The effect was studied of chronic alcohol intake in the rat during pregnancy and lactation on the brown adipose tissue (BAT) in pups. The idea was to find a possible relationship to cot death since in some cot death victims increased amounts of BAT have been observed. Exposure to ethanol increased the relative weight of the brown adipose tissue in pups and enhanced both its total protein content and the activities of the oxidative enzymes, succinate dehydrogenase and cytochrome oxidase. In the BAT of pups sympathetic activity, as demonstrated by noradrenaline, was also increased by long-term exposure to alcohol. In theory, an increased thermogenic capacity of the BAT in the newborn together with other factors such as emotional stress and infections could lead to death from hyperthermia, in which case only non-specific morphological signs would be found in the cadaver.
研究了孕期和哺乳期大鼠长期摄入酒精对幼崽棕色脂肪组织（BAT）的影响。这样做的目的是找出与婴儿猝死综合征（cot death）可能存在的关联，因为在一些婴儿猝死综合征受害者身上观察到棕色脂肪组织的量有所增加。接触乙醇会增加幼崽棕色脂肪组织的相对重量，并提高其总蛋白含量以及氧化酶、琥珀酸脱氢酶和细胞色素氧化酶的活性。在幼崽的棕色脂肪组织中，长期接触酒精也会增加去甲肾上腺素所显示的交感神经活性。从理论上讲，新生儿棕色脂肪组织产热能力的增加，再加上情绪压力和感染等其他因素，可能导致体温过高而死亡，在这种情况下，尸体中只会发现非特异性的形态学迹象。
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