Lin Patrick P, Kang Hyun Guy, Kim Yong-il, Kim June Hyuk, Kim Han Soo
Department of Orthopaedic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Orthopaedic Oncology Clinic, National Cancer Center, Gyeonggido, Republic of Korea.
Surg Oncol. 2015 Sep;24(3):226-31. doi: 10.1016/j.suronc.2015.05.003. Epub 2015 May 22.
Pathologic or osteoporotic femoral neck fractures usually treated with joint replacement surgery rather than joint-preserving surgery because multiple screw fixation has a high risk for fixation failure and nonunion as well as the need for a postoperative protection period. However, joint-preserving surgery might be preferable in high-risk patients with short life expectancy due to advanced disease. Recently introduced hollow-perforated screws are devices for achieving percutaneous fixation by simultaneous injection to the weak bone area through its multiple side holes. We report our experience of surgical treatment of femoral neck fractures by controlled bone cement injection into the femoral head and neck through a modified hollow-perforated screw in patients with advanced cancer.
We modified the hollow perforated screw with variable placing of screw-side holes as fracture patterns. Polymethylmethacrylate (PMMA) bone cement was injected through the screw holes to control its injection into the selective areas of the femoral head and neck while avoiding the fracture sites. One or two of these were fixed percutaneously in 12 patients who have Garden stage I or II femoral neck fractures in the advanced state of advanced cancer. Seven patients had pathologic fracture by metastatic cancer, but 5 had osteoporotic fractures.
Eleven patients died a mean of 4.1 months after surgery and 1 patient lived with ability to walk for 48 months. Sixteen modified hollow perforated-screws and 16 standard cannulated screws were used for fixation. The mean volume of cement injection was 13.8 ml. The complication developed in 4 patients: cement leakage to the hip joint in 2 patients, subtrochanteric fracture in 1 patient (5 months after surgery) and fixation failure in 1 patients (2 months after surgery). Nine patients could walk with or without a walking aid, and all others also could return to the prefracture-ambulation state with effective pain relief on the third postoperative day.
This current surgical method could be useful in patients with short life expectancy because of quick pain relief, early return to ambulation, simple operative procedures and short hospital stay. The modified hollow perforated screw which has a diversity of side hole locations for the regulation of bone cement injection into the planned area seems useful for selective femoral neck fractures.
病理性或骨质疏松性股骨颈骨折通常采用关节置换手术而非保关节手术治疗,因为多枚螺钉固定存在固定失败和骨不连的高风险,且术后需要保护期。然而,对于因晚期疾病预期寿命较短的高危患者,保关节手术可能更可取。最近推出的空心多孔螺钉是一种通过其多个侧孔同时向薄弱骨区域注射以实现经皮固定的装置。我们报告了通过改良空心多孔螺钉将骨水泥控制性注入晚期癌症患者股骨头和颈部来治疗股骨颈骨折的手术经验。
我们根据骨折类型改变螺钉侧孔位置对空心多孔螺钉进行改良。通过螺钉孔注入聚甲基丙烯酸甲酯(PMMA)骨水泥,以控制其注入股骨头和颈部的选定区域,同时避开骨折部位。对12例处于晚期癌症进展期、Garden I 或 II 型股骨颈骨折的患者经皮固定1枚或2枚改良螺钉。7例患者为转移性癌导致的病理性骨折,但5例为骨质疏松性骨折。
11例患者术后平均4.1个月死亡,1例患者存活且能行走48个月。使用了16枚改良空心多孔螺钉和16枚标准空心螺钉进行固定。骨水泥平均注入量为13.8毫升。4例患者出现并发症:2例患者骨水泥漏入髋关节,1例患者术后5个月发生转子下骨折,1例患者术后2个月出现固定失败。9例患者可借助或不借助助行器行走,其他患者在术后第三天疼痛有效缓解后也能恢复到骨折前的行走状态。
由于能快速缓解疼痛、早期恢复行走、手术操作简单且住院时间短,这种手术方法对预期寿命较短的患者可能有用。具有多种侧孔位置以调节骨水泥注入计划区域的改良空心多孔螺钉似乎对选择性股骨颈骨折有用。