Katsumata Shinichi, Matsuzaki Hiroshi, Uehara Mariko, Suzuki Kazuharu
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture.
J Nutr Sci Vitaminol (Tokyo). 2015;61(2):195-200. doi: 10.3177/jnsv.61.195.
We investigated the effects of dietary calcium (Ca) supplementation on bone metabolism, kidney mineral concentrations, and kidney function in rats fed a high-phosphorus (P) diet. Wistar strain rats were randomly divided into 4 dietary groups and fed their respective diets for 21 d: a diet containing 0.3% P and 0.5% Ca (C), a diet containing 1.5% P and 0.5% Ca (HP), a diet containing 0.3% P and 1.0% Ca (HCa), or a diet containing 1.5% P and 1.0% Ca (HPCa). Compared to the C group, the high-P diet increased serum parathyroid hormone concentration, markers of bone turnover, receptor activator of NF-κB ligand mRNA expression of the femur, kidney Ca and P concentrations, urinary N-acetyl-β-D-glucosaminidase activity, and urinary β2-microglobulin excretion, and decreased bone mineral content and bone mineral density of the femur and tibia. Dietary Ca supplementation improved the parameters of bone metabolism and kidney function in rats fed the high-P diet, while there were no significant differences in kidney Ca or P concentrations between the HP and HPCa groups. These results suggest that dietary Ca supplementation prevented the bone loss and decline in kidney function induced by a high-P diet, whereas dietary Ca supplementation did not affect kidney mineral concentrations in rats fed the high-P diet.
我们研究了膳食补充钙（Ca）对高磷（P）饮食喂养大鼠的骨代谢、肾脏矿物质浓度和肾功能的影响。将Wistar品系大鼠随机分为4个饮食组，并分别喂养各自的饮食21天：含0.3% P和0.5% Ca的饮食（C组）、含1.5% P和0.5% Ca的饮食（HP组）、含0.3% P和1.0% Ca的饮食（HCa组）或含1.5% P和1.0% Ca的饮食（HPCa组）。与C组相比，高磷饮食增加了血清甲状旁腺激素浓度、骨转换标志物、股骨中核因子κB受体活化因子配体mRNA表达、肾脏钙和磷浓度、尿N-乙酰-β-D-氨基葡萄糖苷酶活性以及尿β2-微球蛋白排泄，并降低了股骨和胫骨的骨矿物质含量和骨矿物质密度。膳食补充钙改善了高磷饮食喂养大鼠的骨代谢和肾功能参数，而HP组和HPCa组之间的肾脏钙或磷浓度没有显著差异。这些结果表明，膳食补充钙可预防高磷饮食诱导的骨质流失和肾功能下降，而膳食补充钙对高磷饮食喂养大鼠的肾脏矿物质浓度没有影响。
