使用 18F-FDG PET 监测自身免疫性边缘性脑炎的免疫治疗效果。

Monitoring the Effect of Immunotherapy in Autoimmune Limbic Encephalitis Using 18F-FDG PET.

机构信息

From the Departments of *Neurology and †Nuclear Medicine, Clínica Universidad de Navarra, Pamplona, Spain.

出版信息

Clin Nucl Med. 2015 Sep;40(9):e441-3. doi: 10.1097/RLU.0000000000000839.

Abstract

A 70-year-old woman with a history of autoimmune hepatitis and renal cell carcinoma presented with subacute cognitive impairment. A brain MRI revealed mild leukoaraiosis, whereas brain F-FDG PET/CT showed diffuse cerebral hypometabolism that resembled some of the patterns described in limbic encephalitis and neurodegenerative diseases. With the suspicion of autoimmune encephalitis, the patient received immunotherapy with dramatic improvement of cognitive function and metabolic normalization at the 2-month follow-up on brain F-FDG PET/CT. Our results demonstrate that brain F-FDG PET/CT might be a useful tool in the assessment of patients with autoimmune encephalitis.

摘要

一位 70 岁女性，有自身免疫性肝炎和肾细胞癌病史，表现为亚急性认知障碍。脑部 MRI 显示轻度脑白质疏松，而脑部 F-FDG PET/CT 显示弥漫性脑代谢低下，类似于边缘性脑炎和神经退行性疾病中描述的一些模式。考虑自身免疫性脑炎的可能性，患者接受免疫治疗后，认知功能显著改善，在脑部 F-FDG PET/CT 随访 2 个月时代谢恢复正常。我们的结果表明，脑部 F-FDG PET/CT 可能是评估自身免疫性脑炎患者的有用工具。