Saint Martin Magali, Roche Frédéric, Thomas Thierry, Collet Philippe, Barthélémy Jean Claude, Sforza Emilia
Service De Physiologie Clinique Et De L'exercice, CHU Nord, Saint-Etienne, Faculté De Médecine Jacques Lisfranc, Université Jean Monnet, Saint-Etienne, France.
Communautés d'universités et établissements (COMUE), PRES Université De Lyon, France.
Obesity (Silver Spring). 2015 Jul;23(7):1511-6. doi: 10.1002/oby.21121. Epub 2015 Jun 7.
Obesity and aging are considered risk factors for developing sleep apnea syndrome (OSA). The aim of this study was to determine the association between body fat composition and OSA in healthy elderly subjects examined in a 7-year longitudinal study.
A total of 209 elderly with unrecognized OSA aged 68.3 ± 0.8 years underwent a clinical, ambulatory nocturnal respiratory recording, and anthropometric as well as body fat composition assessment by dual-energy X-ray absorptiometry (DEXA) at baseline and follow-up.
At study entry, 50.3% of the population showed an apnea+hypopnea index (AHI) <15 with a mean AHI of 16.8 ± 11. At follow-up, a reduction of OSA cases (42%) was evident with a mean AHI of 14.6 ± 10.2. The DEXA data demonstrated that body mass and total lean mass were reduced at follow-up, while central and peripheral fat mass showed a slight increase. Correlation analysis between the changes in DEXA measurements versus the changes in AHI and the indices of nocturnal hypoxemia showed an absence of a statistical correlation.
The lack of correlation between the DEXA measurement changes and the changes in the AHI confirm our previous data on the absence of a central fat mass effect on OSA in the elderly.
肥胖和衰老被认为是发生睡眠呼吸暂停综合征（OSA）的危险因素。本研究的目的是在一项为期7年的纵向研究中，确定健康老年受试者的体脂成分与OSA之间的关联。
共有209名年龄为68.3±0.8岁、未被识别出患有OSA的老年人在基线和随访时接受了临床检查、夜间动态呼吸记录、人体测量以及通过双能X线吸收法（DEXA）进行的体脂成分评估。
在研究开始时，50.3%的人群呼吸暂停低通气指数（AHI）<15，平均AHI为16.8±11。在随访时，OSA病例明显减少（42%），平均AHI为14.6±10.2。DEXA数据显示，随访时体重和总瘦体重减少，而中心和外周脂肪量略有增加。DEXA测量值的变化与AHI变化以及夜间低氧血症指标之间的相关性分析显示无统计学相关性。
DEXA测量变化与AHI变化之间缺乏相关性，证实了我们之前关于老年人群中中心脂肪量对OSA无影响的数据。
