Lumb B M, Cervero F
Department of Physiology, University of Bristol Medical School, U.K.
Brain Res. 1989 Oct 23;500(1-2):400-4. doi: 10.1016/0006-8993(89)90339-9.
Ventromedial forebrain structures were stimulated electrically with short (10-ms) trains of pulses to test for effects on a viscerosomatic reflex. Stimulation at many hypothalamic sites led to an attenuation or even a complete inhibition of reflex activity. The most sensitive sites, however (i.e. those requiring currents of 50 microA or less to inhibit the reflex), were located in the anterior hypothalamus/preoptic area (AH/POA) and rostrally in the diagonal band of Broca (DBB). At certain sites the effects of electrical stimulation were compared with those of microinjection of an excitatory amino acid (DL-homocysteic acid) which is known to excite neuronal cell bodies and not axons. The results of this part of the study indicated that activation of cell bodies located in the ventromedial AH/POA (from the level of the optic chiasma caudally to the level of DBB rostrally) mediate, at least in part, the inhibitory effects on visceral afferent processing. These data are discussed in relation to a possible role of AH/POA in the spinal processing of nociceptive information of visceral origin.
用电刺激前脑内侧结构，采用短（10毫秒）脉冲串来测试对内脏躯体反射的影响。在许多下丘脑部位进行刺激会导致反射活动减弱甚至完全抑制。然而，最敏感的部位（即那些抑制反射所需电流为50微安或更小的部位）位于下丘脑前部/视前区（AH/POA）以及向前位于布罗卡斜角带（DBB）。在某些部位，将电刺激的效果与微量注射兴奋性氨基酸（DL-高半胱氨酸）的效果进行了比较，已知该氨基酸可兴奋神经元细胞体而非轴突。该研究这部分的结果表明，位于腹内侧AH/POA（从视交叉水平向后至DBB水平向前）的细胞体的激活至少部分介导了对内脏传入信息处理的抑制作用。结合AH/POA在内脏源性伤害性信息脊髓处理中可能的作用对这些数据进行了讨论。
