Kawashima S, Yamada Y, Honda K, Tabata T, Naito M, Fujiwara H
Chem Pharm Bull (Tokyo). 1989 Sep;37(9):2485-90. doi: 10.1248/cpb.37.2485.
Stabilization of bacampicillin (BAPC) in suspension was examined by the addition of alginic acid (Alg). BAPC formed a slightly water-soluble adduct (BAPC-Alg) with Alg, in which BAPC and Alg were presumed to be linked by ionic bonding. However, the suspension of this chemically stable adduct showed a lability to a suspension of BAPC alone; chemically very unstable particles of BAPC base were deposited in the suspension. In contrast, when BAPC-Alg adduct was suspended in 1.0% Alg solution at the same pH region, the precipitation of the particles of BAPC base were not observed. This stabilization is supposed to be due not only to the chemical stability of the adduct, but also to an inhibition of the deposition of an unstable BAPC base particles by Alg.
通过添加海藻酸（Alg）来研究巴卡西林（BAPC）在混悬液中的稳定性。BAPC与Alg形成了一种微溶于水的加合物（BAPC-Alg），其中BAPC和Alg推测是通过离子键相连。然而，这种化学稳定的加合物的混悬液相较于单独的BAPC混悬液表现出不稳定性；化学性质非常不稳定的BAPC碱颗粒沉积在混悬液中。相反，当BAPC-Alg加合物在相同pH范围的1.0%Alg溶液中混悬时，未观察到BAPC碱颗粒的沉淀。这种稳定性被认为不仅归因于加合物的化学稳定性，还归因于Alg对不稳定的BAPC碱颗粒沉积的抑制作用。
